Chronic lymphocytic leukaemiasmall lymphocytic lymphoma

Chronic lymphocytic leukaemiasmall lymphocytic lymphoma meaning.

Forfatter

Blix, Egil Støre; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Forfang, Lise; Tierens, Anne; Myklebust, June; Kolstad, Arne

Sammendrag

Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy.

B-cell receptor (BCR) and co-receptor CD40 signaling is essential for normal B cells, and there is increasing evidence that signaling via BCR and CD40 plays an important role in the pathogenesis of B-cell lymphoma.

Chronic lymphocytic leukaemiasmall lymphocytic lymphoma disorder

The aim of this study was to investigate basal and induced signaling in lymphoma B cells and infiltrating T cells in single-cell suspensions of biopsies from small cell lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and marginal zone lymphoma (MZL) patients.

Samples from untreated SLL/CLL and MZL patients were examined for basal and activation induced signaling by phospho-specific flow cytometry. A panel of 9 stimulation conditions tar